Recent results confirm that long‐term expression of therapeutic transgenes can be achieved by using a transposon‐based system in primary stem cells and in vivo. Transposable elements are natural DNA transfer vehicles that are capable of efficient genomic insertion. The latest generation, Sleeping Beauty transposon‐based hyperactive vector (SB100X), is able to address the basic problem of non‐viral approaches – that is, low efficiency of stable gene transfer. The combination of transposon‐based non‐viral gene transfer with the latest improvements of non‐viral delivery techniques (...) could provide a long‐term therapeutic effect without compromising biosafety. The new challenges of pre‐clinical research will focus on further refinement of the technology in large animal models and improving the safety profile of SB vectors by target‐selected transgene integration into genomic “safe harbors.” The first clinical application of the SB system will help to validate the safety of this approach. (shrink)

The Rev’d Roland Allen’s grandson ventures to speculate on the attitudes his grandfather might be expected to have adopted regarding several of today’s controversial issues. After rehearsing briefly Roland’s published and unpublished work, Hubert Allen reviews, both on the basis of Roland’s expressed opinions and by inference from remarks made by him or by members of his immediate family, how he believes his grandfather would have reacted to six matters of current or recent controversy, namely: Modern Translations of the (...) Bible, The Role of Women in the Church, Homosexuality, Ecumenism, Inter-Faith Dialogue, and the proposed Anglican Covenant. (shrink)

The fundamental ideas concerning computation and recursion naturally find their place at the interface between logic and theoretical computer science. The contributions in this book, by leaders in the field, provide a picture of current ideas and methods in the ongoing investigations into the pure mathematical foundations of computability theory. The topics range over computable functions, enumerable sets, degree structures, complexity, subrecursiveness, domains and inductive inference. A number of the articles contain introductory and background material which it is hoped will (...) make this volume an invaluable resource for specialists and non-specialists alike. (shrink)

Recent new paradigms of computation, based on biological and physical models, address in a radically new way questions of efficiency and challenge assumptions ...

Logicians and theoretical physicists will also benefit from this book.

Together, Models and Computability and its sister volume Sets and Proofs will provide readers with a comprehensive guide to the current state of mathematical logic. All the authors are leaders in their fields and are drawn from the invited speakers at 'Logic Colloquium '97' (the major international meeting of the Association of Symbolic Logic). It is expected that the breadth and timeliness of these two volumes will prove an invaluable and unique resource for specialists, post-graduate researchers, and the informed and (...) interested nonspecialist. (shrink)

Ethics in Mental Health-Substance Use aims to explore the comprehensive concerns and dilemmas occurring from mental health and substance use problems, and to inform, develop, and educate by sharing and pooling knowledge, and enhancing expertise, in this fast developing region of ethics and ethical care and practice. This volume concentrates on ethical concerns, dilemmas, and concepts specifically interrelated, as a collation of problem(s) that directly or indirectly affect the life of the individual and family. Whilst presenting a balanced view of (...) what is ethically best practice today, this title challenges concepts and stimulates debate, exploring all aspects of the development in treatment, intervention and care responses, and the adoption of research-led best practice. (shrink)

Intensive care physicians often must rely on substitute decision makers to address all dimensions of the construct of.

Studies in the psychology and phenomenology of religious experience have long acknowledged similarities with various forms of psychopathology. Consequently, it has been important for religious practitioners and mental health professionals to establish criteria by which religious, spiritual, or mystical experiences can be differentiated from psychopathological experiences. Many previous attempts at differential diagnosis have been based on limited textual accounts of mystical experience or on outdated theoretical studies of mysticism. In contrast, this study presents qualitative data from contemporary Buddhist meditation practitioners (...) and teachers to identify salient features that can be used to guide differential diagnosis. The use of certain existing criteria is complicated by Buddhist worldviews that some difficult or distressing experiences may be expected as a part of progress on the contemplative path. This paper argues that it is important to expand the framework for assessment in both scholarly and clinical contexts to include not only criteria for determining normative fit with religious experience or with psychopathology, but also for determining need for intervention, whether religious or clinical. Qualitative data from Buddhist communities shows that there is a wider range of experiences that are evaluated as potentially warranting intervention than has previously been discussed. Decision making around these experiences often takes into account contextual factors when determining appraisals or need for intervention. This is in line with person-centered approaches in mental health care that emphasize the importance of considering the interpersonal and cultural dynamics that inevitably constitute the context in which experiences are evaluated and rendered meaningful. (shrink)

Welcome precision is brought to the idea, history, types and motives of ethical investment in what will become an authoritative review of the subject. Marc Cooper is a postgraduate researcher at the European Business Management School, University of Wales, and Bodo Schlegelmilch, recently British Rail Professor of Marketing there, has recently been appointed Professor of Marketing at the American Graduate School of International Management (Thunderbird), Phoenix, Arizona.

While the link between servant leadership and organizational citizenship behavior has been established, the individual-level mechanisms underlying this relationship and its boundary conditions remain poorly understood. In this study, we investigate the salience of the mediating mechanisms of leader–member exchange and psychological empowerment in explaining the process by which servant leaders elicit discretionary OCB among followers. We also examine the role of followers’ proactive personality in moderating the indirect effects of servant leadership on OCB through LMX and psychological empowerment. Analysis (...) of survey data collected from 446 supervisor–subordinate dyads in a large Chinese state-owned enterprise suggests that while servant leadership is positively related to subordinate OCB through LMX, psychological empowerment does not explain any additional variance in OCB above that accounted for by LMX. Moderated mediation tests confirm the moderating effect of proactive personality through LMX. By providing a nuanced understanding of how and when servant leadership leads followers to go above and beyond their job role, our study assists organizations in deciding how to develop and utilize servant leaders in their organizations. (shrink)

Social scientists have investigated many facets of popular music over the last 25 years. The vast majority of their efforts have focused on men and their contributions to the creation and performance of popular music. As a result, we know little about women and their experiences as musicians in a traditionally male-centered and male-dominated activity. In this study, the authors used in-depth interviews with 15 local-level female rock and roll musicians in two U.S. cities to explore audiences' reactions and responses (...) to them as performers and their interactions with other band members. (shrink)